虎扑电竞 虎扑电竞

Gut Microbiota Induces the Secretion of Maternal Antibodies in Breastmilk

Breastfeeding offers an array of benefits for mothers and newborns. Maternal antibodies are transferred via breastfeeding, protecting the gastrointestinal tracts of babies from several pathogen-caused infections. Yet the molecular mechanism by which maternal antibodies, especially immunoglobulin A (IgA), are produced in mothers during lactation still puzzles scientists.

Now, a research group led by Tomonori Nochi from Tohoku University's Graduate School of Agricultural Science has discovered that an interorgan network between the mammary glands and the small intestine plays an essential role in maternal antibody transfer through breastfeeding.

Details of their research were published in the journal Cell Reports on September 7, 2021.

Nochi states the research was linked to a need to develop an immune strategy that enhances the quality and quantity of maternal IgA in milk. "In the past, scientists have struggled to fully comprehend antibody production in lactating mothers. This has hindered the discovery of immunological and microbiological approaches to increasing breastfeeding quality."

The team's research revealed the key part Peyer's patches (PP) - immune sensors found in the gastrointestinal tract - play in producing maternal IgA.

They also identified two crucial bacterium types; Bacteroides acidifaciens and Prevotella buccalis, which cohabitate the gastrointestinal tract of mothers, generate immune responses in PPs through antigen sampling M cells, resulting in IgA-producing plasma cells migrating to the mammary glands.

A schematic that show IgA's producing plasma cells migration from the intestine to the mammary gland ?Nochi et al

"Our results provide significant insights into the development of probiotics that facilitate the transfer of sufficient amounts of maternal antibodies from mother to the neonates via breastfeeding," added Nochi.

Publication Details:

Title: The gut microbiota induces Peyer's patch-dependent secretion of maternal IgA into milk
Authors: Katsuki Usami, Kanae Niimi, Ayumi Matsuo, Yoshihisa Suyama, Yoshifumi Sakai, Shintaro Sato, Kohtaro Fujihashi, Hiroshi Kiyono, Saeka Uchino, Mutsumi Furukawa, Jahidul Islam, Kaori Ito, Taiki Moriya, Yutaka Kusumoto, Michio Tomura, Russell C. Hovey, Junichi Sugawara, Hiroshi Yoneyama, Haruki Kitazawa, Kouichi Watanabe, Hisashi Aso, Tomonori Nochi
Journal: Cell Reports
DOI: 10.1016/j.celrep.2021.109655

Press release in Japanese

虎扑电竞:

Tomonori Nochi
Tohoku University Graduate School of Agricultural Science
Email: nochitohoku.ac.jp
Website: https://www.agri.tohoku.ac.jp/keitai/index.html

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